I have some strange interests and one them is trying to keep up to date on
the pathophysiology and etiology of CP. Some of the causes of CP that I am
familiar with include:
- mom having an increased risk of bleeding (type of hemophilia) or
clotting during her pregnancy.
- mom having an bacterial infection/virus during her pregnancy causing a
spike in temperature
- mom having a viral/bacterial infection in her birth canal at the time
of birth
- mom having increased stress during her pregnancy (particulary if she
lives in an area of high crime/violence/tension)
- mom having a poor diet during her pregnancy
- mom having a poorly defined placenta and blood supply to the
embryo/fetus
All of these except for the diet can cause a change in the
fetal/embryo/neonate's heart rate and blood pressure which then can cause
the "brain injury" (aka static encephalopathy) that is commonly found in
people with cerebral palsy.
However, in premature infants there is an artery called the Heubner artery
near the fourth ventricle in the brain which does not have good collateral
(replacement circulation if needed) that is very vulnerable to injury from
changes in BP and HR. If this area is compromised by these changes the nerve
fibers for the legs are affected. If there is a sinificant affect/damage
here then the trunk and arm fibers are affected.
Here ends the anatomy lesson...I have not heard of genetic causes of CP...
Take care and hope everyone is having a great summer.
Greta
Here
On Wed, Jul 30, 2008 at 1:45 PM, Kendall D. Corbett <
[log in to unmask]> wrote:
> Linda,
>
> Sounds like a plausible explanation of some cases of CP, but many,
> if not most are caused by birth trauma and premature birth.
>
> On Wed, Jul 30, 2008 at 12:22 PM, Linda Macaulay <[log in to unmask]
> >wrote:
>
> > Here's something I found on BabyCenter -- take a look!
> >
> > Australian study seeks genetic roots of cerebral palsy
> >
> > http://www.babycenter.com/204_australian-study-seeks-genetic-roots-of-
> > cerebral-palsy_5234805.bc
> > (If clicking doesn't work, simply cut and paste the link into your Web
> > browser.)
> >
> >
> > When I first saw the title, I thought "No way!", but then in reading it,
> > maybe...
> >
> > Heck, my mom and I both have Factor V Leiden which is a genetic mutation
> to
> > be more prone to blood clots. When we learned I had it and then mom too,
> we
> > realized that was probably why she had so many miscarriages and that I
> came
> > early...placenta bloodclotting...thus why I must take injections of blood
> > thinner when pregnant and be monitored closely...
> >
> > Any thoughts?
> >
> > Linda
> >
> > -----------------------
> >
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> >
> > http://listserv.icors.org/SCRIPTS/WA-ICORS.EXE?SUBED1=c-palsy
> >
>
>
>
> --
>
>
> Kendall
>
> An unreasonable man (but my wife says that's redundant!)
>
> The reasonable man adapts himself to the world; the unreasonable one
> persists in trying to adapt the world to himself. Therefore, all progress
> depends on the unreasonable man.
>
> -George Bernard Shaw 1856-1950
>
> -----------------------
>
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>
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>
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