Me either.
----- Original Message ----- 
From: "Carol Pearson" <[log in to unmask]>
To: <[log in to unmask]>
Sent: Saturday, November 11, 2006 5:08 AM
Subject: Re: Anybody awake out there in computer land


> Lyn,
>
> It didn't touch me!  <GRRR>
>
> --
> Carol - Reading, UK
>
> To you, o Lord, I lift up my soul;
> In You I trust, o my God.  . . .."  PS25:1-2 NIV.
>
>
> ----- Original Message ----- 
> From: "Lyn Latham" <[log in to unmask]>
> To: <[log in to unmask]>
> Sent: Friday, November 10, 2006 3:47 PM
> Subject: Re: Anybody awake out there in computer land
>
>
>> Oh man!  This sleep thing is really horrible.  So, I have something that 
>> might help us all.  Although I have tried this medicine and it didn't 
>> work. Do you guys know about this?  They are stating in this article that 
>> sometimes it works if you take it and then stop.  Here I have copy pasted 
>> it for you all.  I try not to send attachments or forwards.  Try this 
>> out.
>> Psychiatr News September 1, 2006
>> Volume 41, Number 17, page 26
>> © 2006
>> American Psychiatric Association
>> Clinical & Research News
>> Melatonin Effective In Totally Blind People
>> Lynne Lamberg
>> Melatonin corrects circadian-rhythm disturbances that often lead to 
>> severe and persistent insomnia in individuals who are totally blind.
>> Totally blind people-those who cannot perceive light-often report 
>> difficulty falling asleep and staying asleep, as well as fatigue, poor 
>> concentration,
>> and irritability while awake.
>> More than half of these individuals, an estimated 50,000 to 100,000 
>> people in the United States alone, may have a potentially correctable 
>> circadian-rhythm
>> sleep disorder, sleep specialists say.
>> Exogenous melatonin is the treatment of choice for blind people with 
>> non-24-hour sleep-wake disorder," said robert Sack, M.D., a professor of 
>> psychiatry
>> at Oregon Health and Science University (OHSU) in Portland.
>> Sack chaired a symposium on using melatonin in the blind at the annual 
>> meeting of the associated Professional Sleep Societies (APSS) in Salt 
>> Lake City,
>> Utah, in June. He and other speakers recently discussed their research 
>> with Psychiatric News.
>> The high prevalence of sleep problems in the blind underscores the 
>> importance of light in regulating circadian rhythms in the sighted, Sack 
>> said. In sighted
>> people, sunlight signals travel from the eyes to the body's master 
>> biological clock in the hypothalamus over a pathway distinct from that 
>> for vision. Shifting
>> levels of light across the day entrain, or synchronize, the sleep-wake 
>> cycle, endogenous melatonin release, and other biological rhythms with 
>> the earth's
>> day/night cycle.
>> Most people, sighted and blind, have innate daily cycles of 24-25 hours, 
>> noted Alfred Lewy, M.D., professor and senior vice chair of psychiatry at 
>> OHSU.
>> In sighted people, daily exposure to sunlight automatically resets cycle 
>> length to the world's 24-hour day. More than half of totally blind people 
>> have
>> a 24.5-hour circadian cycle, Lewy said. They commonly drift later and 
>> later around the real time clock, a phenomenon known as "free-running."
>> Even if they try to sleep at regular times, they typically sleep well 
>> only a few days a month, when their internal clocks fall in sync with 
>> preferred schedules.
>> At other times, they sleep poorly and feel drowsy while awake. Some 
>> experience depressive symptoms.
>> Daily oral doses of melatonin can entrain these blind free-runners, 
>> researchers at the University of Surrey in the United Kingdom reported in 
>> January 2000
>> in the Journal of Endocrinology.
>> Lewy's group suggests doses of about 0.02-0.3 mg/day, approximating 
>> physiological secretion, usually taken in the late afternoon or early 
>> evening, may
>> be
>> most effective. They published a dose-response curve for use of exogenous 
>> melatonin in the physiological range in totally blind people in 
>> Chronobiology
>> International in December 2005.
>> Jonathan Emens, M.D., an assistant professor of psychiatry at OHSU, 
>> working with Lewy and others, reported at the APSS meeting that his group 
>> had shown
>> for the first time that exogenous melatonin also can entrain blind 
>> free-runners with periods less than 24 hours. The researchers helped a 
>> blind 41-year-old
>> woman and a blind 9-year-old girl stop drifting earlier around the clock. 
>> (The long-term safety of giving melatonin to prepubertal children has not 
>> been
>> established.)
>> Melatonin also may help blind people with 24-hour rhythms that 
>> persistently run early or late, disrupting work and social life, Emens 
>> said. Melatonin shifts
>> biological rhythms earlier or later depending on when it is taken.
>> Findings from research in the blind, he suggested, may be applicable to 
>> shift work, jet travel, and other circadian sleep disorders.
>> Figure 1
>> ©
>> iStockphoto.com/hidesy
>> Determining the optimal dose and timing of melatonin administration for 
>> the individual user is a key focus of ongoing research, said Debra Skene, 
>> Ph.D.,
>> a professor of neuroendocrinology at the School of Biomedical and 
>> Molecular Sciences, University of Surrey in Guildford, Surrey, United 
>> Kingdom. An individual's
>> response to melatonin depends on both clock time and circadian time, she 
>> said, and on how long the person takes it.
>> Individual circadian cycle length also may affect treatment outcome, 
>> Skene said. People with an innate period longer than 24.5 hours seem to 
>> have more
>> trouble
>> entraining than those with shorter cycles. Different formulations of 
>> melatonin, including fast release, sustained release, and controlled 
>> release, may
>> have different effects.
>> Before treatment starts, every patient needs a correct diagnosis, said 
>> Steven Lockley, Ph.D., an assistant professor of medicine at Harvard 
>> Medical School.
>> "I know of blind people with non-24-hour sleep-wake disorder who have 
>> been given hypnotics to use at night and stimulants to use in the day 
>> because their
>> physicians did not recognize the cyclic nature of their disorder," he 
>> said.
>> An estimated 1 in 4 totally blind people can entrain to 24-hour rhythms 
>> using nonphotic time cues in their environment, Lockley noted. These cues 
>> include
>> regular times for sleep, meals, exercise, work, social relationships, 
>> caffeine, and medications. Some blind people with no conscious light 
>> perception still
>> may have light-sensitive cells in the retina that enable entrainment.
>> Blind people able to perceive any light are unlikely to have a circadian 
>> rhythm sleep disorder, he said. However, visually impaired people overall 
>> have
>> higher rates of sleep disorders than people with normal vision.
>> Asking a patient to keep a sleep diary or wear a wrist activity monitor 
>> for at least two months probably will reveal a cyclic sleep-wake disorder 
>> if one
>> exists, he said. Collection of urine samples every four to eight hours 
>> for 48 hours every two weeks for two months to assess melatonin or 
>> cortisol rhythms
>> can help make a definitive diagnosis and aid a decision about appropriate 
>> treatment timing. These noninvasive, relatively inexpensive measures, he 
>> said,
>> are practical in primary care practice.
>> Melatonin may improve sleep regardless of circadian entrainment, he 
>> added, but correcting an underlying circadian disorder, if one is 
>> present, can improve
>> daytime performance, alertness, and overall quality of life.
>> : 11/8/2006
>> ----- Original Message ----- 
>> From: "VIRGIE UNDERWOOD" <[log in to unmask]>
>> To: <[log in to unmask]>
>> Sent: Friday, November 10, 2006 3:41 AM
>> Subject: Re: Anybody awake out there in computer land
>>
>>
>>> Apparently it is not going to happen here tonight!
>>> Virgie and Hoshi
>>> ----- Original Message ----- 
>>> From: "Vicki and The Rors" <[log in to unmask]>
>>> To: <[log in to unmask]>
>>> Sent: Friday, November 10, 2006 2:22 AM
>>> Subject: Re: Anybody awake out there in computer land
>>>
>>>
>>>> Yes.  And you should too.  Right?
>>>>
>>>> Vicki
>>>>
>>>> ----- Original Message ----- 
>>>> From: "VIRGIE UNDERWOOD" <[log in to unmask]>
>>>> To: <[log in to unmask]>
>>>> Sent: Thursday, November 09, 2006 11:04 PM
>>>> Subject: Re: Anybody awake out there in computer land
>>>>
>>>>
>>>>> So far sleep is escaping me!  I am wide awake and wish I were 
>>>>> sleeping!
>>>>> We can have all the caffine we want this weekend!  Heck, it is the 
>>>>> weekend isn't it?  You should be off work tomorrow shouldn't you?
>>>>> Virgie and Hoshi
>>>>> ----- Original Message ----- 
>>>>> From: "Vicki and The Rors" <[log in to unmask]>
>>>>> To: <[log in to unmask]>
>>>>> Sent: Friday, November 10, 2006 12:45 AM
>>>>> Subject: Re: Anybody awake out there in computer land
>>>>>
>>>>>
>>>>>>I hope both of us can sleep.  Sure makes a long day when you don't 
>>>>>>sleep. I feel like some green tea, but then, that has caffeine in it. 
>>>>>>Oh well, save it for the weekend.
>>>>>>
>>>>>> Hugs,
>>>>>> Vicki
>>>>>>
>>>>>> ----- Original Message ----- 
>>>>>> From: "VIRGIE UNDERWOOD" <[log in to unmask]>
>>>>>> To: <[log in to unmask]>
>>>>>> Sent: Thursday, November 09, 2006 10:32 PM
>>>>>> Subject: Re: Anybody awake out there in computer land
>>>>>>
>>>>>>
>>>>>>> Well I guess I don't have any reason to complain, this is the first 
>>>>>>> night in a few weeks I haven't been able to sleep!  I hope you are 
>>>>>>> able to get some good sleep tonight.
>>>>>>> Huggs,
>>>>>>> Virgie and Hoshi
>>>>>>> ----- Original Message ----- 
>>>>>>> From: "Vicki and The Rors" <[log in to unmask]>
>>>>>>> To: <[log in to unmask]>
>>>>>>> Sent: Friday, November 10, 2006 12:29 AM
>>>>>>> Subject: Re: Anybody awake out there in computer land
>>>>>>>
>>>>>>>
>>>>>>>> Oh what a bummer Virgie.  I'm thinking about trying that.  Praying 
>>>>>>>> you soon can rest and get much needed sleep.
>>>>>>>>
>>>>>>>> Vicki
>>>>>>>>
>>>>>>>> ----- Original Message ----- 
>>>>>>>> From: "VIRGIE UNDERWOOD" <[log in to unmask]>
>>>>>>>> To: <[log in to unmask]>
>>>>>>>> Sent: Thursday, November 09, 2006 10:21 PM
>>>>>>>> Subject: Anybody awake out there in computer land
>>>>>>>>
>>>>>>>>
>>>>>>>>> Hello,
>>>>>>>>> Is anyone awake out there tonight?  I went to bed but couldn't get 
>>>>>>>>> to sleep!
>>>>>>>>> Virgie and Hoshi
>>>
>>>
>>> -- 
>>> No virus found in this incoming message.
>>> Checked by AVG Free Edition.
>>> Version: 7.1.409 / Virus Database: 268.14.1/527 - Release Date: 
>>> 11/9/2006
>>>
>>>
>
>
> -- 
> No virus found in this incoming message.
> Checked by AVG Free Edition.
> Version: 7.1.409 / Virus Database: 268.14.1/527 - Release Date: 11/9/2006
>