Thu, 26 May 2005 19:06:28 -0600 Wally Day <[log in to unmask]> asked:

>Also, I am wondering how many of these studies have been done with raw
>milk.


It would not be relevant whether the milk was raw or pasteurized. The opioid
peptides in question are derived from casein, a protein found, in varying
quantities, in the milk of all mammals. (Casein forms about 80% of cow's
milk proteins and about 40% of human milk proteins.)

My Master's thesis explores this view of ADHD/ADD in some depth. Please see:

http://www.gluten-free.org/hoggan/adhd.txt
or
www.dangerousgrains.com     and follow the links.

There is also some fascinating new research that shows altered blood flow
patterns in the brain of untreated celiac disease patients (1,2,3) which may
also be a function of exogenous opioid peptides that reach the brain. The
focus of this work is in the context of celiac disease. These patients
experience an increase in zonulin production which has been shown to
increase intestinal permeability and blood-brain-barrier permeability
(4,5,6) thus providing these partly digested proteins with exceptional
access to the brain.

Since ~70% of celiac children are ADD, this may well have implications for
others with ADD and related disorders.


Best Wishes,
Ron Hoggan

Sources:
1.  Abenavoli L, Leggio L, Di Giuda D, Gasbarrini G, Addolorato G.
Neurologic disorders in patients with celiac disease: are they mediated by
brain perfusion changes? Pediatrics. 2004 Dec;114(6):1734; author reply
1734. No abstract available.

2.  Usai P, Serra A, Marini B, Mariotti S, Satta L, Boi MF, Spanu A, Loi G,
Piga M.  Frontal cortical perfusion abnormalities related to gluten intake
and associated autoimmune disease in adult coeliac disease: 99mTc-ECD brain
SPECT study. Dig Liver Dis. 2004 Aug;36(8):513-8.

3.  Addolorato G, Di Giuda D, De Rossi G, Valenza V, Domenicali M, Caputo F,
Gasbarrini A, Capristo E, Gasbarrini G.  Regional cerebral hypoperfusion in
patients with celiac disease. Am J Med. 2004 Mar 1;116(5):312-7.

4. Smecuol E, Sugai E, Niveloni S, Vazquez H, Pedreira S, Mazure R, Moreno
ML, Label M, Maurino E, Fasano A, Meddings J, Bai JC. Permeability, zonulin
production, and enteropathy in dermatitis herpetiformis.Clin Gastroenterol
Hepatol. 2005 Apr;3(4):335-41.
5.  Clemente MG, De Virgiliis S, Kang JS, Macatagney R, Musu MP, Di Pierro
MR, Drago S, Congia M, Fasano A.  Early effects of gliadin on enterocyte
intracellular signalling involved in intestinal barrier function.
Gut. 2003 Feb;52(2):218-23.

6.  Fasano A, Not T, Wang W, Uzzau S, Berti I, Tommasini A, Goldblum SE.
Zonulin, a newly discovered modulator of intestinal permeability, and its
expression in coeliac disease. Lancet. 2000 Apr 29;355(9214):1518-9.