-----Original Message-----
From: NIH Neuroscience Seminar Series Announcements
[mailto:[log in to unmask]] On Behalf Of Wang, Gladys
(NIH/NINDS)
Sent: Friday, April 16, 2004 12:02
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Subject: NIH Neuroscience Seminar Series Announcement


2004 NIH Neuroscience Seminar Series
Monday, April 19 , 2004,  Noon
Building 10, Lipsett Amphitheater

RICHARD PALMITER, PH.D.,  University of Washington/HHMI

 "Dopamine and Motivated Behaviors"

The major focus of research in the Palmiter laboratory involves analysis
of the developmental and behavioral consequences of inactivating mouse
genes necessary for neurotransmitter signaling.   The lab has produced
knockout mice that cannot produce dopamine, norepinephrine or
neuropeptide Y.  Current efforts are centered on four areas.  First, the
lab is exploring the relationship between dopamine and reward.  The lab
uses viral transduction to restore dopamine signaling in specific brain
regions to gain insight into where in the brain dopamine is required for
certain behaviors. The second area focuses on the role of norepinephrine
in regulating various processes including, sleep, withdrawal from
morphine addiction and glucose homeostasis. The third area involves the
role hypothalamic neurons that make neuropeptide Y (NPY) and
agouti-related protein (AgRP) in the regulation of energy balance.  A
fourth area of investigation is directed towards making a mouse model of
Parkinson's disease.  (From
http://www.gs.washington.edu/faculty/palmiter.htm )
Selected Publications:

Palmiter R.D. (2004) Protection Against Zinc Toxicity by Metallothionein
and Zinc Transporter 1.  Proc Natl. Acad. Sci. USA 101, 4918-4923.
Denenberg, V.H., Kim D.S and Palmiter R. D. (2004) The Role of Dopamine
in Learning, Memory, and Performance of a Water Escape Task. Behav Br
Res 148, 73-78.
Cannon, C.M. and Palmiter, R.D. (2003) Reward without Dopamine. J.
Neurosci. 23, 10827-10831.
Ste Marie, L and Palmiter R.D. (2003) Norepinephrine and
Epinephrine-deficient Mice Are Hyperinsulinemic and Have Lower Blood
Glucose.  Endocrinology 144, 4427-4432.
Kim D.S., Froelick, G.J., and Palmiter, R.D. (2002) Dopamine-dependent
Desensitization of Dopaminergic Signaling in the Developing Mouse
Striatum.  J. Neurosci. 22, 9841-9849.
Lee, J-Y., Cole, T.B., Palmiter, R.D., Suh, S. W. and Koh, J-Y. (2002)
Contribution of Synaptic Zinc to the Gender-disparate Plaque Formation
in Human Swedish Mutant APP Transgenic mice.  Proc Natl. Acad. Sci USA
99, 7705-7710.
For more information see our website -  http://neuroseries.info.nih.gov
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