Don Wiss wrote:

> I forwarded the above to Loren. He replied:
>
> You can go to my website: www.thepaleodiet.com under FAQ and read
> about the
> molecular basis on how saturated fats promote atherosclerosis by down
> regulating the LDL receptor.  The nobel prize in medicine was awarded to
> Brown and Goldstein for this discovery.


Here's a link to the Brown-Goldstein lab:
http://www8.utsouthwestern.edu/utsw/cda/dept14857/files/114532.html

I don't think I'll ever reach a point where I'm satisfied that I
understand what's going on with cholesterol, but my working hypothesis
(on which I guess you could say I'm betting my life) is that it is the
small-dense LDL subfraction that causes the reaction that Brown and
Goldstein describe (but saturated fat downregulates the hepatic
receptors of *all* LDL), so it is the small-dense LDL, rather than
overall LDL, that is "bad."  And small-dense LDL is correlated with
triglycerides...

Todd Moody
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