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In a message dated 11/22/02 3:44:36 PM, [log in to unmask] writes:
>Grand Forks Human Nutrition Research Center
>> http://www.gfhnrc.ars.usda.gov/news/nws9903a.htm
Went to this site. It talked about copper deficiency, but saw nothing about
vitamin C. Seems that copper deficiency is involved with nitric oxide and
arterial function. Funny -- vitamin C is also involved and in fact has been
used directly in opening arteries. A paragraph from a vitamin C paper I did a
couple of years ago:
studies reviewed by Gaytan and Prisant (2001) discovered that for patients
with diabetes, endothelium-dependent vasodilation was improved short term by
the vitamin C infusion into the brachial artery. Patients with congestive
heart failure have impaired flow-dependent vasodilation. This has been
attributed in part to increased oxidants. The review by Gaytan and Prisant
(2001) reported on studies with patients with congestive heart failure. In
one study it was demonstrated that baseline radial artery dysfunction was
completely restored with intra-arterial vitamin C. The nitrous
oxide–dependent portion of the dysfunction was also normalized with vitamin
C. In theory, vitamin C increases the effects of endothelium-derived nitric
oxide by blocking oxidants such as superoxide and oxidized low-density
lipoprotein (LDL). Vitamin C is proposed to spare intracellular glutathione
and regenerate vitamin E. Further evidence of this mechanism was noted in a
study of vitamin C in coronary spastic angina. Patients with angiographically
proven coronary spasm during acetylcholine infusion were restored to a normal
vasodilation response by intracoronary infusion of vitamin C. Tolerance to
nitrates is theorized to be secondary to the formation of superoxides that
inhibit endothelial nitric oxide. A placebo controlled group of 20 patients
with congestive heart failure demonstrated maintenance of the effects of
intravenous nitroglycerin on main pulmonary artery pressure and pulmonary
capillary wedge pressure with an intravenous infusion of vitamin C at 18
hours. The vitamin placebo group experienced degradation of the effects of
intravenous nitroglycerin on the pulmonary capillary wedge pressure and in
the pulmonary artery pressure. Vitamin E levels were preserved in the
ascorbic acid infusion group and declined in the placebo group.
Namaste, Liz
<A HREF="http://www.csun.edu/~ecm59556/Healthycarb/index.html">
http://www.csun.edu/~ecm59556/Healthycarb/index.html</A>
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