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Don't know whether you've seen this -- similar reasoning that Wiley and
Formby give in Lights Out concerning evolutionary advantage of insulin
resistance. Will have to get the whole article.
Eur J Clin Nutr 2002 Mar;56 Suppl 1:S30-5 Related Articles, Links
The 'carnivore connection'--evolutionary aspects of insulin resistance.
Colagiuri S, Brand Miller J.
Department of Endocrinology, Diabetes and Metabolism, Prince of Wales
Hospital, Sydney, Australia. [log in to unmask]
Insulin resistance is common and is determined by physiological (aging,
physical fitness), pathological (obesity) and genetic factors. The metabolic
compensatory response to insulin resistance is hyperinsulinaemia, the primary
purpose of which is to maintain normal glucose tolerance. The 'carnivore
connection' postulates a critical role for the quantity of dietary protein
and carbohydrate and the change in the glycaemic index of dietary
carbohydrate in the evolution of insulin resistance and hyperinsulinaemia.
Insulin resistance offered survival and reproductive advantages during the
Ice Ages which dominated human evolution, during which a high-protein
low-carbohydrate diet was consumed. Following the end of the last Ice Age and
the advent of agriculture, dietary carbohydrate increased. Although this
resulted in a sharp increase in the quantity of carbohydrate consumed, these
traditional carbohydrate foods had a low glycaemic index and produced only
modest increases in plasma insulin. The industrial revolution changed the
quality of dietary carbohydrate. The milling of cereals made starch more
digestible and postprandial glycaemic and insulin responses increased 2-3
fold compared with coarsely ground flour or whole grains. This combination of
insulin resistance and hyperinsulinaemia is a common feature of many modern
day diseases. Over the last 50 y the explosion of convenience and takeaway
'fast foods' has exposed most populations to caloric intakes far in excess of
daily energy requirements and the resulting obesity has been a major factor
in increasing the prevalence of insulin resistance.
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_u
ids=11965520&dopt=Abstract
Namaste, Liz
<A HREF="http://www.csun.edu/~ecm59556/Healthycarb/index.html">
http://www.csun.edu/~ecm59556/Healthycarb/index.html</A>
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