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Date: | Tue, 31 Oct 2000 09:50:41 -0500 |
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On Mon, 30 Oct 2000, Cave Chick wrote:
> Thanks for the response Todd. Any suggestions on where I could read up more
> on LDL elevation following rapid weight loss in women?
Sure, right here...
Todd Moody
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Title
The transient hypercholesterolemia of major weight loss.
Author
Phinney SD; Tang AB; Waggoner CR; Tezanos-Pinto RG; Davis PA
Source
Am J Clin Nutr, 1991 Jun, 53:6, 1404-10
Abstract
Serum lipoproteins, body composition, and adipose
cholesterol contents of six obese women were studied
during and after major weight loss by very-low-calorie
diets (VLCDs). Subjects started at 168 +/- 11% of ideal
body weight, lost 30.3 +/- 3.7 kg in 5-7 mo, followed by
2+ mo in weight maintenance. Serum cholesterol fell from
a prediet (baseline) value of 5.49 +/- 0.32 to 3.62 +/-
0.31 mmol/L (P less than 0.01) after 1-2 mo of VLCDs
(nadir), after which it rose to 5.95 +/- 0.36 mmol/L
(peak, P less than 0.01 compared with nadir and baseline)
as weight loss continued. With weight maintenance, serum
cholesterol fell to 4.92 +/- 0.34 mmol/L (P less than 0.05
compared with peak). Adipose cholesterol content did not
change in peripheral (arm and leg) biopsy sites but rose
significantly in abdominal adipose tissue with weight
loss. We conclude that major weight loss was associated
with a late rise in serum cholesterol, possibly from
mobilization of adipose cholesterol stores, which resolved
when weight loss ceased.
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